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Lupus and Overlap
Mixed Connective Tissue Disease

Some individuals have symptoms and signs of three connective tissue diseases, i.e., lupus, polymyositis-dermatomyositis, and scleroderma. At any given time, the combination of problems encountered by the patient may vary considerably, from no active disease to features of one, two, or all three of these conditions at the same time. These persons often (but not always) have one specific blood antibody in their blood (anti-U1RNP antibody) but not the other antibodies commonly associated with SLE, SSc, or PM-DM. Whether this is an entirely separate disease, or a situation in which one person has three diseases, remains uncertain. However, the presence of a single blood antibody is a strong point in favor of a distinctive disease. As in the other circumstances mentioned above, treatment should be individualized and directed at the particular problems present at any given time.
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Prognosis For People With Lupus And Overlap Syndromes
It is important for those with lupus to be aware of the symptoms that might indicate the development of "overlap" features, since these symptoms and abnormalities may be best managed with treatments not typically used for lupus. Fortunately, when an overlap syndrome is present, the symptoms characteristic of the other connective tissue diseases involved are usually mild

UCTD, Mischkollagenose (MCTD) und andere Überlappungssyndrome

Undifferenzierte Kollagenosen (UCTD) und Überlappungssyndrome mit klinischen Manifestationen eines SLE (Kap. 3.11) weisen in der Regel eine bessere Prognose und eine geringere Häufigkeit von schweren viszeralen Manifestationen auf. Die medikamentöse Therapiestrategie bei diesen Erkrankungen folgt den oben ausgeführten Grundsätzen zur Behandlung des SLE, ohne dass hierfür Daten aus kontrollierten Studien vorliegen.